| pubmed-article:9588872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0162867 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C2246343 | lld:lifeskim |
| pubmed-article:9588872 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9588872 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9588872 | pubmed:dateCreated | 1998-6-3 | lld:pubmed |
| pubmed-article:9588872 | pubmed:abstractText | Mechanical strain reportedly stimulates the synthesis of collagen in vascular smooth muscle cells (SMCs). The present study was designed to investigate a possible involvement of angiotensin II (Ang II) and transforming growth factor (TGF)-beta in stretch-induced collagen synthesis of cultured SMCs derived from the rabbit aortic media. SMCs were cyclically stretched at a rate of 10% elongation and 30 cycles/min for 24 h using the Flexercell strain unit (Flexcell International Corp., McKeesport, Pa.). A two-fold increase in collagen synthesis and a concurrent increase in total protein synthesis were noted in stretched SMCs. Concentration of immunoreactive Ang II in the conditioned medium was elevated under the mechanical strain. Stretch-induced collagen and total protein synthesis were inhibited by either a selective antagonist to Ang II (saralasin), an angiotensin I-converting enzyme inhibitor (captopril) or an antisense oligonucleotide for angiotensinogen mRNA. An elevated secretion of TGF-beta, both active and latent forms, was found in the medium of stretched SMCs. Saralasin inhibited the stretch-induced secretion of TGF-beta from SMCs. Stretch-induced collagen and total protein synthesis was further inhibited by either an anti-TGF-beta1 neutralizing antibody or an adenovirus-mediated transfer of a truncated TGF-beta type II receptor. Elevated expression of collagen alpha1(III) chain and TGF-beta1 mRNAs, and its reversal by saralasin were also demonstrated in stretched SMCs. Results indicate that the stretch-induced collagen and total protein synthesis appears to be mediated via an autocrine-paracrine mechanism of Ang II and TGF-beta released from SMCs. | lld:pubmed |
| pubmed-article:9588872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9588872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9588872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9588872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9588872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9588872 | pubmed:issn | 1018-1172 | lld:pubmed |
| pubmed-article:9588872 | pubmed:author | pubmed-author:OoshimaAA | lld:pubmed |
| pubmed-article:9588872 | pubmed:author | pubmed-author:UenoHH | lld:pubmed |
| pubmed-article:9588872 | pubmed:author | pubmed-author:LUEE | lld:pubmed |
| pubmed-article:9588872 | pubmed:author | pubmed-author:MuragakiYY | lld:pubmed |
| pubmed-article:9588872 | pubmed:author | pubmed-author:HatamuraII | lld:pubmed |
| pubmed-article:9588872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9588872 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:9588872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9588872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9588872 | pubmed:pagination | 93-103 | lld:pubmed |
| pubmed-article:9588872 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:9588872 | pubmed:articleTitle | Stretch-induced collagen synthesis in cultured smooth muscle cells from rabbit aortic media and a possible involvement of angiotensin II and transforming growth factor-beta. | lld:pubmed |
| pubmed-article:9588872 | pubmed:affiliation | First Department of Pathology, Wakayama Medical College, Japan. | lld:pubmed |
| pubmed-article:9588872 | pubmed:publicationType | Journal Article | lld:pubmed |
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