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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-6-9
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pubmed:abstractText |
T cell tolerance to parenchymal self-antigens is thought to be induced by encounter of the T cell with its cognate peptide-major histocompatibility complex (MHC) ligand expressed on the parenchymal cell, which lacks appropriate costimulatory function. We have used a model system in which naive T cell receptor (TCR) transgenic hemagglutinin (HA)-specific CD4+ T cells are adoptively transferred into mice expressing HA as a self-antigen on parenchymal cells. After transfer, HA-specific T cells develop a phenotype indicative of TCR engagement and are rendered functionally tolerant. However, T cell tolerance is not induced by peptide-MHC complexes expressed on parenchymal cells. Rather, tolerance induction requires that HA is presented by bone marrow (BM)-derived cells. These results indicate that tolerance induction to parenchymal self-antigens requires transfer to a BM-derived antigen-presenting cell that presents it to T cells in a tolerogenic fashion.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1339454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1385722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1439825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1534823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1694042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1730913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1900951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1901764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1901765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-1972594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2113314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2125368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2148123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2511629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2526197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2531293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2653373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-2747651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-6091906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-6294095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7502042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7512724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7513904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7534199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7561041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7566174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7621869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7686860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7710713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-7889419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8006585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8097319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8241051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8600538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8759720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8777718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8809125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-8977322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-9053441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-9133420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9584134-9221753
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1555-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells.
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pubmed:affiliation |
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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