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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5366
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pubmed:dateCreated |
1998-6-4
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pubmed:databankReference |
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pubmed:abstractText |
RasGRP, a guanyl nucleotide-releasing protein for the small guanosine triphosphatase Ras, was characterized. Besides the catalytic domain, RasGRP has an atypical pair of "EF hands" that bind calcium and a diacylglycerol (DAG)-binding domain. RasGRP activated Ras and caused transformation in fibroblasts. A DAG analog caused sustained activation of Ras-Erk signaling and changes in cell morphology. Signaling was associated with partitioning of RasGRP protein into the membrane fraction. Sustained ligand-induced signaling and membrane partitioning were absent when the DAG-binding domain was deleted. RasGRP is expressed in the nervous system, where it may couple changes in DAG and possibly calcium concentrations to Ras activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras-GRF1
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9582122-Amino Acid Sequence,
pubmed-meshheading:9582122-Animals,
pubmed-meshheading:9582122-Brain,
pubmed-meshheading:9582122-Calcium,
pubmed-meshheading:9582122-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9582122-Catalysis,
pubmed-meshheading:9582122-Cell Cycle Proteins,
pubmed-meshheading:9582122-Cell Line,
pubmed-meshheading:9582122-Cell Membrane,
pubmed-meshheading:9582122-Cell Size,
pubmed-meshheading:9582122-Cell Transformation, Neoplastic,
pubmed-meshheading:9582122-Cloning, Molecular,
pubmed-meshheading:9582122-DNA, Complementary,
pubmed-meshheading:9582122-DNA-Binding Proteins,
pubmed-meshheading:9582122-Diglycerides,
pubmed-meshheading:9582122-Genes, ras,
pubmed-meshheading:9582122-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:9582122-Guanosine Diphosphate,
pubmed-meshheading:9582122-Guanosine Triphosphate,
pubmed-meshheading:9582122-Molecular Sequence Data,
pubmed-meshheading:9582122-Neurons,
pubmed-meshheading:9582122-Phosphoprotein Phosphatases,
pubmed-meshheading:9582122-Rats,
pubmed-meshheading:9582122-Recombinant Fusion Proteins,
pubmed-meshheading:9582122-Signal Transduction,
pubmed-meshheading:9582122-ras Proteins,
pubmed-meshheading:9582122-ras-GRF1
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pubmed:year |
1998
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pubmed:articleTitle |
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.
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pubmed:affiliation |
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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