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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-5-21
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pubmed:abstractText |
The synthesis of suramin analogues bearing a 2-phenyl-benzimidazole moiety is described. Aminoarene sulfonic acids 2a-e are acylated with 3,4-dinitrobenzoyl chloride 3 yielding the amides 4a-e which are hydrogenated to the corresponding diamines 5a-e. These are treated with 3-nitrobenzaldehyde, yielding the azomethines 7a-e and their isomers 8a-e and 9a-e. Key step in the synthesis of the target compounds 12a-e is the oxidation of the azomethines with oxygen to the benzimidazoles 10a-e. These are hydrogenated to the amines 11a-e reacting with phosgene to yield the symmetric ureas 12a-e. Results of the anti-HIV, cytostatic, and antiangiogenic screening are presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0365-6233
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
331
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-103
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9557135-Anti-HIV Agents,
pubmed-meshheading:9557135-Antineoplastic Agents,
pubmed-meshheading:9557135-Benzenesulfonates,
pubmed-meshheading:9557135-Cells, Cultured,
pubmed-meshheading:9557135-Drug Evaluation, Preclinical,
pubmed-meshheading:9557135-Humans,
pubmed-meshheading:9557135-Naphthalenesulfonates,
pubmed-meshheading:9557135-Sulfanilic Acids,
pubmed-meshheading:9557135-Suramin
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pubmed:year |
1998
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pubmed:articleTitle |
Suramin analogues with a 2-phenylbenzimidazole moiety as partial structure; potential anti HIV- and angiostatic drugs, 2: Sulfanilic acid-, benzenedisulfonic acid-, and naphthalenetrisulfonic acid analogues.
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pubmed:affiliation |
Pharmazeutisches Institut, Universität Bonn, Germany.
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pubmed:publicationType |
Journal Article
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