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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1998-6-4
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pubmed:abstractText |
Intraperitoneal injection of 1,25-(OH)2D3 4 micrograms/kg was given to 84 calcium- and vitamin D-repleted Wistar rats and samples of plasma, duodenal mucosa and renal tissue were taken after 0, 3, 6, 12, 24, 48 and 96 hr (n = 12 at each time interval). Plasma-ionized Ca increased after 6 hr, reached a maximum after 24 hr and returned to the initial values after 96 hr. The concentrations of renal calbindin-D28k and intestinal calbindin-D9k did not increase until 48 hr after injection and remained elevated until 96 hr after. Therefore, significantly elevated concentrations of the cytosolic calbindin-D were found at a time with normal values of plasma Ca. The present data suggest that calbindin-D does not alone increase the transcellular Ca transport and, therefore, supports the view that calbindin-Ds may serve as Ca buffer proteins.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0901-9928
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9553988-Animals,
pubmed-meshheading:9553988-Calcitriol,
pubmed-meshheading:9553988-Calcium,
pubmed-meshheading:9553988-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:9553988-Intestines,
pubmed-meshheading:9553988-Kidney,
pubmed-meshheading:9553988-Male,
pubmed-meshheading:9553988-Rats,
pubmed-meshheading:9553988-Rats, Wistar
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pubmed:year |
1998
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pubmed:articleTitle |
The effect of 1,25-vitamin D3 on calbindin-D and calcium-metabolic variables in the rat.
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pubmed:affiliation |
Department of Nephrology, Rigshospitalet, University of Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|