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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-4-30
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pubmed:abstractText |
We have identified three distinct populations of mouse lymph node dendritic cells (DC) that differ in their capacity to uptake Ag delivered by different routes, and in their dynamics. The "I-DCs" are large cells that resemble the interdigitating cells and have a mature phenotype and a slow turnover. They derive from the regional tissues. The "sm-DCs" and "sI-DCs" are smaller (hence s-DC), have a more immature phenotype and a rapid turnover. The sI-DC phenotype, including CD8alpha expression suggests a lymphoid-related origin. The sI-DC population is expanded 100-fold after an in vivo flt3 ligand treatment. The sm-DC phenotype suggests a myeloid-related origin. Interestingly, sm-DCs can acquire i.v. injected macromolecules in less than 30 min after injection. They may, therefore, play an important role in the immune response against blood Ags.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
708-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9551906-Animals,
pubmed-meshheading:9551906-Antigens, CD11,
pubmed-meshheading:9551906-Biological Markers,
pubmed-meshheading:9551906-Cell Cycle,
pubmed-meshheading:9551906-Cell Differentiation,
pubmed-meshheading:9551906-Dendritic Cells,
pubmed-meshheading:9551906-Dextrans,
pubmed-meshheading:9551906-Fluorescein-5-isothiocyanate,
pubmed-meshheading:9551906-Hematopoiesis,
pubmed-meshheading:9551906-Histocompatibility Antigens Class II,
pubmed-meshheading:9551906-Injections, Intraperitoneal,
pubmed-meshheading:9551906-Injections, Intravenous,
pubmed-meshheading:9551906-Lymph Nodes,
pubmed-meshheading:9551906-Macromolecular Substances,
pubmed-meshheading:9551906-Membrane Proteins,
pubmed-meshheading:9551906-Mice,
pubmed-meshheading:9551906-Mice, Inbred C57BL,
pubmed-meshheading:9551906-Mice, Inbred CBA,
pubmed-meshheading:9551906-Mice, Inbred DBA,
pubmed-meshheading:9551906-Mice, Transgenic,
pubmed-meshheading:9551906-Skin
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pubmed:year |
1998
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pubmed:articleTitle |
Three populations of mouse lymph node dendritic cells with different origins and dynamics.
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pubmed:affiliation |
Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Université Pierre et Marie Curie, Centre National de la Recherche Scientifique, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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