9551703

Source:http://linkedlifedata.com/resource/pubmed/id/9551703

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0016277, umls-concept:C0025519, umls-concept:C0064113, umls-concept:C0082525, umls-concept:C0126174, umls-concept:C0547047
pubmed:issue	6
pubmed:dateCreated	1998-6-2
pubmed:abstractText	Losartan is metabolised to its active metabolite E-3174 by CYP2C9 and CYP3A4 in vitro. Itraconazole is an inhibitor of CYP3A4, whereas fluconazole affects CYP2C9 more than CYP3A4. We wanted to study the possible interaction of these antimycotics with losartan in healthy volunteers.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1256165
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/CYP2C9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/EXP3174, http://linkedlifedata.com/resource/pubmed/chemical/Fluconazole, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Itraconazole, http://linkedlifedata.com/resource/pubmed/chemical/Losartan, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Steroid 16-alpha-Hydroxylase, http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0031-6970
pubmed:author	pubmed-author:KaukonenK MKM, pubmed-author:NeuvonenP JPJ, pubmed-author:OlkkolaK TKT
pubmed:issnType	Print
pubmed:volume	53
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	445-9
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:9551703-Adult, pubmed-meshheading:9551703-Antifungal Agents, pubmed-meshheading:9551703-Antihypertensive Agents, pubmed-meshheading:9551703-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:9551703-Cross-Over Studies, pubmed-meshheading:9551703-Cytochrome P-450 CYP3A, pubmed-meshheading:9551703-Cytochrome P-450 Enzyme System, pubmed-meshheading:9551703-Double-Blind Method, pubmed-meshheading:9551703-Drug Interactions, pubmed-meshheading:9551703-Female, pubmed-meshheading:9551703-Fluconazole, pubmed-meshheading:9551703-Humans, pubmed-meshheading:9551703-Imidazoles, pubmed-meshheading:9551703-Itraconazole, pubmed-meshheading:9551703-Losartan, pubmed-meshheading:9551703-Male, pubmed-meshheading:9551703-Mixed Function Oxygenases, pubmed-meshheading:9551703-Reference Values, pubmed-meshheading:9551703-Steroid 16-alpha-Hydroxylase, pubmed-meshheading:9551703-Steroid Hydroxylases, pubmed-meshheading:9551703-Tetrazoles
pubmed:year	1998
pubmed:articleTitle	Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174.
pubmed:affiliation	Department of Clinical Pharmacology, University of Helsinki, Finland. maija.jalava@helsinki.fi
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't