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rdf:type |
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lifeskim:mentions |
umls-concept:C0012222,
umls-concept:C0024485,
umls-concept:C0031001,
umls-concept:C0034693,
umls-concept:C0079284,
umls-concept:C0205314,
umls-concept:C0205374,
umls-concept:C0221198,
umls-concept:C0231491,
umls-concept:C0387926,
umls-concept:C0456389,
umls-concept:C0475224,
umls-concept:C0599946,
umls-concept:C0679622,
umls-concept:C0740391,
umls-concept:C2603343
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pubmed:issue |
4
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pubmed:dateCreated |
1998-5-1
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pubmed:abstractText |
Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain ischemia and may worsen the ischemic damage. Diffusion-weighted MRI (DWI) and perfusion imaging (PI) are powerful tools for evaluation of acute cerebral ischemia. We studied the effects of A-127722, a novel ET(A)-selective ET antagonist, on cerebral ischemic lesion size using 2,3,5-triphenyltetrazolium chloride (TTC) staining postmortem, on acute ischemic lesion development with DWI, and on the cerebral circulation using PI.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
850-7; discussion 857-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9550522-Acute Disease,
pubmed-meshheading:9550522-Administration, Oral,
pubmed-meshheading:9550522-Animals,
pubmed-meshheading:9550522-Arterial Occlusive Diseases,
pubmed-meshheading:9550522-Binding, Competitive,
pubmed-meshheading:9550522-Biological Availability,
pubmed-meshheading:9550522-Cerebral Arterial Diseases,
pubmed-meshheading:9550522-Diffusion,
pubmed-meshheading:9550522-Ischemic Attack, Transient,
pubmed-meshheading:9550522-Magnetic Resonance Imaging,
pubmed-meshheading:9550522-Male,
pubmed-meshheading:9550522-Perfusion,
pubmed-meshheading:9550522-Pyrrolidines,
pubmed-meshheading:9550522-Rats,
pubmed-meshheading:9550522-Rats, Sprague-Dawley,
pubmed-meshheading:9550522-Receptors, Endothelin
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pubmed:year |
1998
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pubmed:articleTitle |
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study.
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pubmed:affiliation |
Department of Neurology, Helsinki University Central Hospital, Finland. turgut.tatlisumak@helsinki.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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