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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-5-29
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pubmed:abstractText |
The effect of drugs in the fetus can be thought of in terms of the dose-response based on a knowledge of the general principles by which drug is transferred from the mother to the fetus. Fetal drug concentration, which determines the fetal response, is a function of the maternal concentration, the placental permeability, the fetal drug clearance, and differences in protein binding and ionization between the maternal and fetal plasma.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0889-8545
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-42
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9547758-Animals,
pubmed-meshheading:9547758-Female,
pubmed-meshheading:9547758-Fetus,
pubmed-meshheading:9547758-Humans,
pubmed-meshheading:9547758-Maternal-Fetal Exchange,
pubmed-meshheading:9547758-Models, Biological,
pubmed-meshheading:9547758-Pharmacokinetics,
pubmed-meshheading:9547758-Placenta,
pubmed-meshheading:9547758-Pregnancy,
pubmed-meshheading:9547758-Pregnancy Complications,
pubmed-meshheading:9547758-Substance-Related Disorders
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pubmed:year |
1998
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pubmed:articleTitle |
Pharmacology of drug transfer across the placenta.
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pubmed:affiliation |
Department of Pediatrics, College of Physicians and Surgeons, Columbia Univesity, New York, New York, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|