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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-6-8
pubmed:abstractText
The correlation of acto-myosin ATPase rate with tension redevelopment kinetics (k(tr)) was determined during Ca(+2)-activated contractions of demembranated rabbit psoas muscle fibers; the ATPase rate was either increased or decreased relative to control by substitution of ATP (5.0 mM) with 2-deoxy-ATP (dATP) (5.0 mM) or by lowering [ATP] to 0.5 mM, respectively. The activation dependence of k(tr) and unloaded shortening velocity (Vu) was measured with each substrate. With 5.0 mM ATP, Vu depended linearly on tension (P), whereas k(tr) exhibited a nonlinear dependence on P, being relatively independent of P at submaximum levels and rising steeply at P > 0.6-0.7 of maximum tension (Po). With dATP, Vu was 25% greater than control at Po and was elevated at all P > 0.15Po, whereas Po was unchanged. Furthermore, the Ca(+2) sensitivity of both k(tr) and P increased, such that the dependence of k(tr) on P was not significantly different from control, despite an elevation of Vu and maximal k(tr). In contrast, lowering [ATP] caused a slight (8%) elevation of Po, no change in the Ca(+2) sensitivity of P, and a decrease in Vu at all P. Moreover, k(tr) was decreased relative to control at P > 0.75Po, but was elevated at P < 0.75Po. These data demonstrate that the cross-bridge cycling rate dominates k(tr) at maximum but not submaximum levels of Ca(2+) activation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1289901, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1400367, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1401036, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1403812, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1420891, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1733945, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-1940850, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2136951, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2243087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2309121, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2455798, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2580968, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2661721, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2939452, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2960681, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2966401, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2967885, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-2969265, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-314510, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3215997, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3410962, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3487312, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3497264, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3795099, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-3871943, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-4255750, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-4545390, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-5316143, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6232958, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6481646, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6611405, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6611412, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6824759, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-6973624, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-7601340, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-7787067, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-7858135, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-7858136, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-7864087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8006815, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8132628, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8160831, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8218897, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8487194, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8572183, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8770217, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8815803, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-8913615, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-9017207, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-9083682, http://linkedlifedata.com/resource/pubmed/commentcorrection/9545059-9172755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2005-15
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Calcium regulation of tension redevelopment kinetics with 2-deoxy-ATP or low [ATP] in rabbit skeletal muscle.
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