rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1998-5-11
|
pubmed:abstractText |
In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0021-8820
|
pubmed:author |
pubmed-author:EnomotoYY,
pubmed-author:FangFF,
pubmed-author:KameiKK,
pubmed-author:MasumaRR,
pubmed-author:OmuraSS,
pubmed-author:ShiomiKK,
pubmed-author:Sugoh-HaginoMM,
pubmed-author:TanakaYY,
pubmed-author:YamaguchiYY,
pubmed-author:ZhangC GCG,
pubmed-author:ZhangX WXW
|
pubmed:issnType |
Print
|
pubmed:volume |
51
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
153-60
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:9544936-Animals,
pubmed-meshheading:9544936-Antifungal Agents,
pubmed-meshheading:9544936-Antimalarials,
pubmed-meshheading:9544936-Fermentation,
pubmed-meshheading:9544936-Humans,
pubmed-meshheading:9544936-Lactones,
pubmed-meshheading:9544936-Macrolides,
pubmed-meshheading:9544936-Mice,
pubmed-meshheading:9544936-Plasmodium berghei,
pubmed-meshheading:9544936-Plasmodium falciparum,
pubmed-meshheading:9544936-Sesquiterpenes,
pubmed-meshheading:9544936-Structure-Activity Relationship
|
pubmed:year |
1998
|
pubmed:articleTitle |
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites.
|
pubmed:affiliation |
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|