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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-4-21
|
| pubmed:abstractText |
Seven AIDS patients who were receiving suppressive therapy for previously diagnosed cytomegalovirus (CMV) retinitis were offered treatment with protease inhibitors (PIs). Secondary prophylaxis for CMV was discontinued after 3 months of therapy with PIs if patients had >150 CD4 cells/mm3 and a human immunodeficiency virus (HIV) load of <200 copies/mL and if they were negative for CMV as determined by qualitative CMV polymerase chain reaction (PCR). Ophthalmologic exams were done periodically. After a median follow-up of 9 months (range, 9-12), no new episodes of CMV retinitis were observed. CD4 cell counts were >150 cells/mm3 in all cases, HIV loads were <200 copies/mL, and results for qualitative CMV PCRs remained negative. These observations suggest that for selected patients with healed CMV retinitis who have immunologic and virologic evidence of a clinical response to potent combination antiretroviral therapy, temporary discontinuation of a chronic anti-CMV suppressive therapy may not result in further retinal necrosis. However, the long-term immunologic benefit of PIs and hence the safety of prolonged withdrawal of anti-CMV therapy is unknown.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Foscarnet,
http://linkedlifedata.com/resource/pubmed/chemical/Ganciclovir,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
177
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1080-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9534987-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9534987-Adult,
pubmed-meshheading:9534987-Anti-HIV Agents,
pubmed-meshheading:9534987-CD4 Lymphocyte Count,
pubmed-meshheading:9534987-Cytomegalovirus,
pubmed-meshheading:9534987-Cytomegalovirus Retinitis,
pubmed-meshheading:9534987-DNA, Viral,
pubmed-meshheading:9534987-Drug Monitoring,
pubmed-meshheading:9534987-Drug Therapy, Combination,
pubmed-meshheading:9534987-Female,
pubmed-meshheading:9534987-Follow-Up Studies,
pubmed-meshheading:9534987-Foscarnet,
pubmed-meshheading:9534987-Ganciclovir,
pubmed-meshheading:9534987-HIV,
pubmed-meshheading:9534987-HIV Protease Inhibitors,
pubmed-meshheading:9534987-Humans,
pubmed-meshheading:9534987-Male,
pubmed-meshheading:9534987-Polymerase Chain Reaction,
pubmed-meshheading:9534987-RNA, Viral,
pubmed-meshheading:9534987-Recurrence,
pubmed-meshheading:9534987-Viral Load
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients.
|
| pubmed:affiliation |
Ophthalmologic Department, Germans Trias i Pujol University Hospital, Badalona, Spain.
|
| pubmed:publicationType |
Journal Article
|