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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-4-13
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pubmed:databankReference |
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pubmed:abstractText |
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is dramatically elevated upon cold exposure of mice in both brown fat and skeletal muscle, key thermogenic tissues. PGC-1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the uncoupling protein (UCP-1) promoter. Ectopic expression of PGC-1 in white adipose cells activates expression of UCP-1 and key mitochondrial enzymes of the respiratory chain, and increases the cellular content of mitochondrial DNA. These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-39
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9529258-Adaptation, Physiological,
pubmed-meshheading:9529258-Adipose Tissue, Brown,
pubmed-meshheading:9529258-Adrenergic beta-Agonists,
pubmed-meshheading:9529258-Amino Acid Sequence,
pubmed-meshheading:9529258-Animals,
pubmed-meshheading:9529258-Body Temperature Regulation,
pubmed-meshheading:9529258-Cloning, Molecular,
pubmed-meshheading:9529258-Cold Temperature,
pubmed-meshheading:9529258-Energy Metabolism,
pubmed-meshheading:9529258-Gene Expression Regulation,
pubmed-meshheading:9529258-Male,
pubmed-meshheading:9529258-Mice,
pubmed-meshheading:9529258-Mice, Inbred C57BL,
pubmed-meshheading:9529258-Molecular Sequence Data,
pubmed-meshheading:9529258-RNA, Messenger,
pubmed-meshheading:9529258-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9529258-Transcription, Genetic,
pubmed-meshheading:9529258-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
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pubmed:affiliation |
Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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