Linked Life Data

9524770

Source:http://linkedlifedata.com/resource/pubmed/id/9524770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-5-18
pubmed:abstractText
Hepatocyte growth factor/scatter factor (HGF/SF) can induce epithelial-mesenchymal conversion of epithelial cells in culture, with the dissociated cells becoming highly motile. The signal given by HGF/SF is mediated by its specific receptor, the c-Met tyrosine kinase. Targeted mutations in the mouse have demonstrated that HGF/SF and c-Met take over functions in development of the placenta, liver and skeletal muscle. During development of skeletal muscle, the receptor and its ligand control migration of myogenic precursor cells in the embryo. These myogenic precursors undergo an epithelial-mesenchymal conversion and detach from the dermomyotome of the somite. They then migrate to different sites in the embryo where they terminally differentiate to form skeletal muscle. Mutations in the HGF/SF or c-met genes abolish emigration of myogenic precursor cells. As a consequence, skeletal muscle groups that derive from migrating cells do not form. Ectopic application of HGF/SF in the chick embryo induces epithelial-mesenchymal conversion and emigration of dermomyotomal cells. Moreover, the expression patterns of HGF/SF and c-Met in the mouse embryo are in accordance with a function of HGF/SF in the induction of epithelial-mesenchymal conversion and the generation of migrating myogenic precursor cells in vivo. The pattern suggests additional roles during the migratory process, which will be discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
212
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-77; discussion 177-82
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development.
pubmed:affiliation
Max-Delbrück-Center for Molecular Medicine, Department of Medical Genetics, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't