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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0035544,
umls-concept:C0035696,
umls-concept:C0080124,
umls-concept:C0185117,
umls-concept:C0332256,
umls-concept:C0456387,
umls-concept:C0700114,
umls-concept:C0851285,
umls-concept:C1167298,
umls-concept:C1511938,
umls-concept:C1517631,
umls-concept:C2347930,
umls-concept:C2911684
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1998-3-24
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|
pubmed:abstractText |
Small alpha-RNP of K-562 cells contain a small RNA as an RNA component, this RNA is homologous to Alu-repeating sequences of human DNA. When cells are exposed to dimethylsulfoxide, an agent inducing cell differentiation along the erythroid pathway, the content of both high-molecular-weight (heterogeneous nuclear and messenger) RNA enriched with Alu repeats and low-molecular-weight specific RNA, small Alu-homologous alpha-RNA undergoes a coordinated decrease. Using the technique of northern blot hybridization, we have demonstrated nonuniform distribution of Alu repeats both in the fraction of total low-molecular-weight RNA of the cytoplasm as well as in the fraction of messenger RNA. It is proposed that alpha-RNA (alpha-RNP) participates in the control of expression of non-linked Alu-containing genes.
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pubmed:language |
rus
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0475-1450
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9518300-Blotting, Northern,
pubmed-meshheading:9518300-Cell Transformation, Neoplastic,
pubmed-meshheading:9518300-Dimethyl Sulfoxide,
pubmed-meshheading:9518300-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9518300-Human Genome Project,
pubmed-meshheading:9518300-Humans,
pubmed-meshheading:9518300-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:9518300-Molecular Weight,
pubmed-meshheading:9518300-Nucleic Acid Hybridization,
pubmed-meshheading:9518300-Plasmids,
pubmed-meshheading:9518300-RNA, Antisense,
pubmed-meshheading:9518300-RNA, Messenger,
pubmed-meshheading:9518300-RNA, Neoplasm,
pubmed-meshheading:9518300-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:9518300-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:9518300-Transcription, Genetic,
pubmed-meshheading:9518300-Tumor Cells, Cultured
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|
pubmed:articleTitle |
[A new class of small RNP (alpha-RNP) containing antisense RNA in K-562 cells. IV. The coordinated regulation of the expression of Alu-containing mRNA and alpha-RNA during differentiation].
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pubmed:affiliation |
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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