Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-4-7
|
| pubmed:abstractText |
The effectiveness of two new topical anesthetics that do not contain cocaine (prilocaine-phenylephrine and bupivacaine-phenylephrine) was compared with that of tetracaine-adrenaline-cocaine (TAC) during laceration repair in children. This study was a prospective, randomized, double-blind trial conducted in the emergency department of a large children's hospital. Participants were 180 children 1 year of age or older with a laceration 5 cm or less in length that required suturing. Pain felt during suturing was scored by suture technicians, research assistants, parents, and patients 5 years of age and older using a visual analogue scale (VAS). There was no statistical difference demonstrated between the effectiveness of prilocaine-phenylephrine and that of TAC for any of the observer groups. A statistically significant difference was seen among anesthetics when comparing VAS scores of research assistants (P = .002), suture technicians (P = .006), and parents (P = .03), but not when comparing VAS ratings of patients (P = .07). Based on Tukey's post hoc test, these statistically significant differences were between TAC and bupivacaine-phenylephrine. When power analyses were performed using alpha = 0.05 and beta = 0.20, it was possible to detect a difference of 1.3 VAS units for each rater group. In conclusion, this study demonstrated the effectiveness and safety of prilocaine-phenylephrine and bupivacaine-phenylephrine. Prilocaine-phenylephrine statistically outperformed bupivacaine-phenylephrine and offers an effective alternative to TAC during laceration repair in children.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Bupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Prilocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetracaine,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0735-6757
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
121-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9517683-Adolescent,
pubmed-meshheading:9517683-Anesthesia, Local,
pubmed-meshheading:9517683-Anesthetics, Local,
pubmed-meshheading:9517683-Bupivacaine,
pubmed-meshheading:9517683-Child,
pubmed-meshheading:9517683-Child, Preschool,
pubmed-meshheading:9517683-Cocaine,
pubmed-meshheading:9517683-Double-Blind Method,
pubmed-meshheading:9517683-Emergency Service, Hospital,
pubmed-meshheading:9517683-Epinephrine,
pubmed-meshheading:9517683-Female,
pubmed-meshheading:9517683-Hospitals, Pediatric,
pubmed-meshheading:9517683-Humans,
pubmed-meshheading:9517683-Infant,
pubmed-meshheading:9517683-Male,
pubmed-meshheading:9517683-Pain,
pubmed-meshheading:9517683-Pain Measurement,
pubmed-meshheading:9517683-Phenylephrine,
pubmed-meshheading:9517683-Prilocaine,
pubmed-meshheading:9517683-Prospective Studies,
pubmed-meshheading:9517683-Safety,
pubmed-meshheading:9517683-Skin,
pubmed-meshheading:9517683-Suture Techniques,
pubmed-meshheading:9517683-Tetracaine,
pubmed-meshheading:9517683-Vasoconstrictor Agents
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Prilocaine-phenylephrine and bupivacaine-phenylephrine topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
|
| pubmed:affiliation |
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|