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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1998-6-18
|
| pubmed:abstractText |
The expression of specialized signal transduction components in mammalian olfactory neurons is thought to be regulated by the O/E (Olf-1/EBF) family of transcription factors. The O/E proteins are expressed in cells of the olfactory neuronal lineage throughout development and are also expressed transiently in neurons in the developing nervous system during embryogenesis. We have identified a C. elegans homologue of the mammalian O/E proteins, which displays greater than 80% similarity over 350 amino acids. Like its mammalian homologues, CeO/E is expressed in certain chemosensory neurons (ASI amphid neurons) throughout development and is also expressed transiently in developing motor neurons when these cells undergo axonal outgrowth. We demonstrate that CeO/E is the product of the unc-3 gene, mutations in which cause defects in the axonal outgrowth of motor neurons, as well as defects in dauer formation, a process requiring chemosensory inputs. These observations suggest that the O/E family of transcription factors play a central and evolutionarily conserved role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0950-1991
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
125
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1561-8
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9502737-Aging,
pubmed-meshheading:9502737-Amino Acid Sequence,
pubmed-meshheading:9502737-Animals,
pubmed-meshheading:9502737-Axons,
pubmed-meshheading:9502737-Base Sequence,
pubmed-meshheading:9502737-Caenorhabditis elegans,
pubmed-meshheading:9502737-Caenorhabditis elegans Proteins,
pubmed-meshheading:9502737-Embryonic Induction,
pubmed-meshheading:9502737-Exons,
pubmed-meshheading:9502737-Gene Expression Regulation, Developmental,
pubmed-meshheading:9502737-Genes, Helminth,
pubmed-meshheading:9502737-Helminth Proteins,
pubmed-meshheading:9502737-Mammals,
pubmed-meshheading:9502737-Molecular Sequence Data,
pubmed-meshheading:9502737-Motor Neurons,
pubmed-meshheading:9502737-Mutagenesis, Site-Directed,
pubmed-meshheading:9502737-Nervous System,
pubmed-meshheading:9502737-Neurons,
pubmed-meshheading:9502737-Point Mutation,
pubmed-meshheading:9502737-Recombinant Proteins,
pubmed-meshheading:9502737-Sequence Alignment,
pubmed-meshheading:9502737-Sequence Homology, Amino Acid,
pubmed-meshheading:9502737-Transcription Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors.
|
| pubmed:affiliation |
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
|
| pubmed:publicationType |
Journal Article
|