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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-4-24
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pubmed:abstractText |
The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-1406932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-1406933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-1406937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-2065352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-2117566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-2123346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-2225071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-2961771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7498366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7553874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7567998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7623813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7623856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7726861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7759107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7774011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7867505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7896838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7925270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7925271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-7937919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8036168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8078893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8248255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8248256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8306876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8355703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8469283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8505281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8620528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8630418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-8962164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-9047395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-9087432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-9224592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9501099-9240432
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1779-87
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9501099-Amino Acid Sequence,
pubmed-meshheading:9501099-Anemia,
pubmed-meshheading:9501099-Animals,
pubmed-meshheading:9501099-DNA-Binding Proteins,
pubmed-meshheading:9501099-Embryonic and Fetal Development,
pubmed-meshheading:9501099-Erythropoiesis,
pubmed-meshheading:9501099-Fetus,
pubmed-meshheading:9501099-Genes, Lethal,
pubmed-meshheading:9501099-Homozygote,
pubmed-meshheading:9501099-Leucine Zippers,
pubmed-meshheading:9501099-Liver,
pubmed-meshheading:9501099-Mice,
pubmed-meshheading:9501099-Mice, Knockout,
pubmed-meshheading:9501099-Molecular Sequence Data,
pubmed-meshheading:9501099-NF-E2-Related Factor 1,
pubmed-meshheading:9501099-Nuclear Respiratory Factor 1,
pubmed-meshheading:9501099-Nuclear Respiratory Factors,
pubmed-meshheading:9501099-RNA, Messenger,
pubmed-meshheading:9501099-Trans-Activators
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pubmed:year |
1998
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pubmed:articleTitle |
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
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pubmed:affiliation |
Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article
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