Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-4-23
|
| pubmed:abstractText |
Novel hydrophilic-hydrophobic block copolymers - poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) (poly(HEMA-block-BSMS) or BH polymer) - were prepared as materials potentially useful for blood-contacting devices. Among the BH(X) series including poly(HEMA) itself, platelet adhesion and activation are minimum on the surface of BH(10), the block copolymer composed of 10 mol% of the hydrophobic segment. The unique physicochemical characteristics of BH(10) such as the high free water content and the increased mobility of PHEMA segments seem to play an important role in the prevention of platelet adhesion and activation. The water content of BH(10) was twice that of poly(HEMA) itself, even in the presence of 10 mol% of the hydrophobic moiety [poly(BSMS)]. Further, an anomalous increase in free water content was observed for the BH(10) sample measured by DSC. The glass transition temperature of BH(10) in the dry state was determined to be c. 10 degrees C, which was much lower than that observed for each of the homopolymers (c.f.: Tg [poly(HEMA)] = 70 degrees C; Tg [poly(BSMS)] = 160 degrees C), suggesting an increased mobility of tethered PHEMA segments in the BH(10) film.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylic Resins,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Gels,
http://linkedlifedata.com/resource/pubmed/chemical/Polyhydroxyethyl Methacrylate,
http://linkedlifedata.com/resource/pubmed/chemical/Water
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0920-5063
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
111-29
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9493840-Acrylic Resins,
pubmed-meshheading:9493840-Animals,
pubmed-meshheading:9493840-Biocompatible Materials,
pubmed-meshheading:9493840-Blood Physiological Phenomena,
pubmed-meshheading:9493840-Blood Platelets,
pubmed-meshheading:9493840-Calcium,
pubmed-meshheading:9493840-Calorimetry, Differential Scanning,
pubmed-meshheading:9493840-Cell Count,
pubmed-meshheading:9493840-Chromatography, Gel,
pubmed-meshheading:9493840-Fluorometry,
pubmed-meshheading:9493840-Gels,
pubmed-meshheading:9493840-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9493840-Microscopy, Electron,
pubmed-meshheading:9493840-Microscopy, Electron, Scanning,
pubmed-meshheading:9493840-Platelet Activation,
pubmed-meshheading:9493840-Platelet Adhesiveness,
pubmed-meshheading:9493840-Polyhydroxyethyl Methacrylate,
pubmed-meshheading:9493840-Rabbits,
pubmed-meshheading:9493840-Surface Tension,
pubmed-meshheading:9493840-Water,
pubmed-meshheading:9493840-Wettability
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Minimized platelet interaction with poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) hydrogel showing anomalously high free water content.
|
| pubmed:affiliation |
Department of Materials Science and Technology, Science University of Tokyo, Noda, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|