rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-3-26
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pubmed:abstractText |
The DNA repair capacities of Neisseria gonorrhoeae have not been well characterised, however, it is known that the gonococcus possesses an excision repair system. The fact that genes in this system are part of the SOS regulon in Escherichia coli prompted this investigation into the transcriptional regulation of genes involved in DNA repair in N. gonorrhoeae. Northern (RNA-DNA) dot blot hybridisation was used to investigate potential DNA damage-mediated induction of the gonococcal recA, uvrA and uvrB genes. In contrast to the situation in E. coli, transcription of these genes in N. gonorrhoeae was not induced in response to treatment with methyl methanesulfonate (MMS) and UV light. These data indicated that the gonococcus does not possess an SOS-like system that is induced in response to DNA damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Methanesulfonate,
http://linkedlifedata.com/resource/pubmed/chemical/Rec A Recombinases,
http://linkedlifedata.com/resource/pubmed/chemical/UvrA protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/UvrB protein, E coli
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9479048-Adenosine Triphosphatases,
pubmed-meshheading:9479048-Bacterial Proteins,
pubmed-meshheading:9479048-Blotting, Northern,
pubmed-meshheading:9479048-DNA Damage,
pubmed-meshheading:9479048-DNA Helicases,
pubmed-meshheading:9479048-DNA Repair,
pubmed-meshheading:9479048-DNA-Binding Proteins,
pubmed-meshheading:9479048-Escherichia coli,
pubmed-meshheading:9479048-Escherichia coli Proteins,
pubmed-meshheading:9479048-Gene Expression Regulation, Bacterial,
pubmed-meshheading:9479048-Methyl Methanesulfonate,
pubmed-meshheading:9479048-Neisseria gonorrhoeae,
pubmed-meshheading:9479048-Rec A Recombinases,
pubmed-meshheading:9479048-SOS Response (Genetics),
pubmed-meshheading:9479048-Ultraviolet Rays
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pubmed:year |
1998
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pubmed:articleTitle |
Absence of an SOS-like system in Neisseria gonorrhoeae.
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pubmed:affiliation |
Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria 3168, Australia. Casilda.Black@med.monash.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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