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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5355
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pubmed:dateCreated |
1998-3-13
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pubmed:abstractText |
The nocturnal increase in circulating melatonin in vertebrates is regulated by 10- to 100-fold increases in pineal serotonin N-acetyltransferase (AA-NAT) activity. Changes in the amount of AA-NAT protein were shown to parallel changes in AA-NAT activity. When neural stimulation was switched off by either light exposure or L-propranolol-induced beta-adrenergic blockade, both AA-NAT activity and protein decreased rapidly. Effects of L-propranolol were blocked in vitro by dibutyryl adenosine 3',5'-monophosphate (cAMP) or inhibitors of proteasomal proteolysis. This result indicates that adrenergic-cAMP regulation of AA-NAT is mediated by rapid reversible control of selective proteasomal proteolysis. Similar proteasome-based mechanisms may function widely as selective molecular switches in vertebrate neural systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Arylamine N-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Melatonin,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1358-60
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:9478897-Adrenergic beta-Agonists,
pubmed-meshheading:9478897-Adrenergic beta-Antagonists,
pubmed-meshheading:9478897-Animals,
pubmed-meshheading:9478897-Arylamine N-Acetyltransferase,
pubmed-meshheading:9478897-Bucladesine,
pubmed-meshheading:9478897-Cyclic AMP,
pubmed-meshheading:9478897-Cysteine Endopeptidases,
pubmed-meshheading:9478897-Cysteine Proteinase Inhibitors,
pubmed-meshheading:9478897-Isoproterenol,
pubmed-meshheading:9478897-Light,
pubmed-meshheading:9478897-Melatonin,
pubmed-meshheading:9478897-Multienzyme Complexes,
pubmed-meshheading:9478897-Pineal Gland,
pubmed-meshheading:9478897-Propranolol,
pubmed-meshheading:9478897-Proteasome Endopeptidase Complex,
pubmed-meshheading:9478897-Rats,
pubmed-meshheading:9478897-Receptors, Adrenergic, beta
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pubmed:year |
1998
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pubmed:articleTitle |
Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation.
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pubmed:affiliation |
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892-4480, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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