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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5-6
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pubmed:dateCreated |
1998-3-30
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pubmed:abstractText |
A retrospective study of hepatosplenic candidiasis in patients with acute leukemia from a single centre was performed. The significance of age, sex, type of leukemia, dose of cytosine arabinoside (Ara-C), duration of neutropenia, steroid use and period of therapeutic antibiotics in the development of hepatosplenic candidiasis was analyzed, using logistic regression analysis. Nine of 51 patients had hepatosplenic candidiasis. Ara-C use was highly associated with the development of hepatosplenic candidiasis (p = 0.001); with a high association with a higher dose (p < 0.0001). On the basis of these results consideration should be given to further trial of antifungal prophylaxis for patients receiving high dose Ara-C.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1042-8194
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
469-74
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9477128-Adult,
pubmed-meshheading:9477128-Antibiotic Prophylaxis,
pubmed-meshheading:9477128-Antimetabolites, Antineoplastic,
pubmed-meshheading:9477128-Candidiasis,
pubmed-meshheading:9477128-Cytarabine,
pubmed-meshheading:9477128-Female,
pubmed-meshheading:9477128-Humans,
pubmed-meshheading:9477128-Leukemia, Myeloid, Acute,
pubmed-meshheading:9477128-Male,
pubmed-meshheading:9477128-Middle Aged,
pubmed-meshheading:9477128-Neutropenia,
pubmed-meshheading:9477128-Opportunistic Infections,
pubmed-meshheading:9477128-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9477128-Retrospective Studies,
pubmed-meshheading:9477128-Risk Factors
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pubmed:year |
1997
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pubmed:articleTitle |
High dose cytosine arabinoside is a major risk factor for the development of hepatosplenic candidiasis in patients with leukemia.
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pubmed:affiliation |
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
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pubmed:publicationType |
Journal Article
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