| pubmed-article:9475667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0005938 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0537670 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0085268 | lld:lifeskim |
| pubmed-article:9475667 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:9475667 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9475667 | pubmed:dateCreated | 1998-3-26 | lld:pubmed |
| pubmed-article:9475667 | pubmed:abstractText | Interleukin (IL)-11 stimulates osteoclast formation and inhibits osteoblast function in vitro and has been implicated in estrogen deficiency-induced bone loss. Herein we report the in vivo effect of recombinant human IL-11 (rHU-IL-11), administered s.c. in doses between 10 and 200 microg/kg/day for 6 weeks into 6-month-old rats after ovariectomy. There was no difference between vehicle-treated and rHu-IL-11 treated rats in the ovariectomy-induced increase in the urinary excretion of pyridinoline and deoxypyridinoline. Neither was there a significant effect of rHu-IL-11 on the plasma concentrations of osteocalcin and on bone mineral density (BMD) measured at a metaphyseal area of the distal femur after 6 weeks. At all dosages tested, rHu-IL-11 increased the femoral diaphyseal area. In conclusion, IL-11 has no deleterious in vivo effect on biochemical parameters of bone remodeling and BMD in estrogen-deficient rats. | lld:pubmed |
| pubmed-article:9475667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9475667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9475667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9475667 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9475667 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:BouillonRR | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:DequekerJJ | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:VerhaegheJJ | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:Van HerckEE | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:KeithJ CJCJr | lld:pubmed |
| pubmed-article:9475667 | pubmed:author | pubmed-author:van BreeRR | lld:pubmed |
| pubmed-article:9475667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9475667 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9475667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9475667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9475667 | pubmed:pagination | 49-53 | lld:pubmed |
| pubmed-article:9475667 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
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| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:meshHeading | pubmed-meshheading:9475667-... | lld:pubmed |
| pubmed-article:9475667 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9475667 | pubmed:articleTitle | Recombinant human interleukin-11 does not modify biochemical parameters of bone remodeling and bone mineral density in adult ovariectomized rats. | lld:pubmed |
| pubmed-article:9475667 | pubmed:affiliation | Department of Obstetrics and Gynecology, Bone Disease Research Unit, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:9475667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9475667 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9475667 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
