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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-3-26
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pubmed:abstractText |
Interleukin (IL)-11 stimulates osteoclast formation and inhibits osteoblast function in vitro and has been implicated in estrogen deficiency-induced bone loss. Herein we report the in vivo effect of recombinant human IL-11 (rHU-IL-11), administered s.c. in doses between 10 and 200 microg/kg/day for 6 weeks into 6-month-old rats after ovariectomy. There was no difference between vehicle-treated and rHu-IL-11 treated rats in the ovariectomy-induced increase in the urinary excretion of pyridinoline and deoxypyridinoline. Neither was there a significant effect of rHu-IL-11 on the plasma concentrations of osteocalcin and on bone mineral density (BMD) measured at a metaphyseal area of the distal femur after 6 weeks. At all dosages tested, rHu-IL-11 increased the femoral diaphyseal area. In conclusion, IL-11 has no deleterious in vivo effect on biochemical parameters of bone remodeling and BMD in estrogen-deficient rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9475667-Amino Acids,
pubmed-meshheading:9475667-Animals,
pubmed-meshheading:9475667-Biological Markers,
pubmed-meshheading:9475667-Body Weight,
pubmed-meshheading:9475667-Bone Density,
pubmed-meshheading:9475667-Bone Remodeling,
pubmed-meshheading:9475667-Bone and Bones,
pubmed-meshheading:9475667-Calcium,
pubmed-meshheading:9475667-Dose-Response Relationship, Drug,
pubmed-meshheading:9475667-Female,
pubmed-meshheading:9475667-Humans,
pubmed-meshheading:9475667-Interleukin-11,
pubmed-meshheading:9475667-Kidney,
pubmed-meshheading:9475667-Organ Size,
pubmed-meshheading:9475667-Osteocalcin,
pubmed-meshheading:9475667-Osteoporosis,
pubmed-meshheading:9475667-Ovariectomy,
pubmed-meshheading:9475667-Rats,
pubmed-meshheading:9475667-Rats, Wistar,
pubmed-meshheading:9475667-Recombinant Proteins,
pubmed-meshheading:9475667-Spleen
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pubmed:year |
1998
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pubmed:articleTitle |
Recombinant human interleukin-11 does not modify biochemical parameters of bone remodeling and bone mineral density in adult ovariectomized rats.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Bone Disease Research Unit, Katholieke Universiteit Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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