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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-4-14
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pubmed:abstractText |
Differentiation of leukemic HL-60 cells by all transretinoic acid (ATRA) resulted in a reduced rate of growth. Cyclosporin A and FK506, at concentrations that inhibited calcineurin activity, abrogated the ATRA-induced inhibition of HL-60 cell growth but these immunosuppressants had no effect on the ATRA-induced granulocytic differentiation. Treatment with 1 microM ATRA led to a progressive increase in calcineurin phosphatase activity of HL-60 cells; the increase in this activity appeared to parallel the functional change of HL-60 cells during granulocytic differentiation. Increase in calcineurin activity was concordant with the increased expressions of calcineurin A and calcineurin B subunit proteins. The FKBP12 expression increased during ATRA-induced differentiation and expression of cyclophilin A remained unchanged. We propose that the increased expression of calcineurin is involved in the ATRA-induced inhibition of HL-60 cell proliferation, as in the case with 1,25alpha-dihydroxy-vitamin D3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidylprolyl Isomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Polyenes,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1019-6439
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-34
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9472103-Calcineurin,
pubmed-meshheading:9472103-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:9472103-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9472103-Calmodulin,
pubmed-meshheading:9472103-Carrier Proteins,
pubmed-meshheading:9472103-Cell Differentiation,
pubmed-meshheading:9472103-Cell Division,
pubmed-meshheading:9472103-Cell Membrane,
pubmed-meshheading:9472103-Cell Nucleus,
pubmed-meshheading:9472103-Cyclosporine,
pubmed-meshheading:9472103-Cytosol,
pubmed-meshheading:9472103-DNA-Binding Proteins,
pubmed-meshheading:9472103-Granulocytes,
pubmed-meshheading:9472103-HL-60 Cells,
pubmed-meshheading:9472103-Heat-Shock Proteins,
pubmed-meshheading:9472103-Humans,
pubmed-meshheading:9472103-Immunosuppressive Agents,
pubmed-meshheading:9472103-Kinetics,
pubmed-meshheading:9472103-Peptidylprolyl Isomerase,
pubmed-meshheading:9472103-Polyenes,
pubmed-meshheading:9472103-Sirolimus,
pubmed-meshheading:9472103-Tacrolimus,
pubmed-meshheading:9472103-Tacrolimus Binding Proteins,
pubmed-meshheading:9472103-Tretinoin
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pubmed:year |
1998
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pubmed:articleTitle |
Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation.
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pubmed:affiliation |
The Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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