| pubmed-article:9469690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9469690 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9469690 | lifeskim:mentions | umls-concept:C0376618 | lld:lifeskim |
| pubmed-article:9469690 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9469690 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9469690 | pubmed:dateCreated | 1998-3-12 | lld:pubmed |
| pubmed-article:9469690 | pubmed:abstractText | We investigated the effect of endotoxemia on alpha1-adrenergic receptor-mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incremental doses of a vasopressor. Twelve male Sprague-Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a continuous infusion of endotoxin (PN-LPS) for 48 hours. Incremental doses of phenylephrine were given and peak MAP response was recorded. The endotoxin group had a decreased rise in MAP with the same dose of phenylephrine compared with the control group (59 +/- 14 and 99 +/- 12 mm Hg, respectively, p<0.001). However, the baseline MAP was higher in the endotoxin group (102 +/- 18 and 71 +/- 7 mm Hg, respectively, p<0.002). The overall maximum effect was the same for both groups (161 +/- 16 and 170 +/- 8 mm Hg, respectively, p=NS). These data indicate that sustained endotoxemia does not result in desensitization of alpha1-adrenergic responsiveness. Other mechanisms are responsible for the ineffectiveness of vasopressors during advanced sepsis. | lld:pubmed |
| pubmed-article:9469690 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9469690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9469690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9469690 | pubmed:issn | 0277-0008 | lld:pubmed |
| pubmed-article:9469690 | pubmed:author | pubmed-author:MasI RIR | lld:pubmed |
| pubmed-article:9469690 | pubmed:author | pubmed-author:LimaJ JJJ | lld:pubmed |
| pubmed-article:9469690 | pubmed:author | pubmed-author:KoppJ EJE | lld:pubmed |
| pubmed-article:9469690 | pubmed:author | pubmed-author:BrownR ORO | lld:pubmed |
| pubmed-article:9469690 | pubmed:author | pubmed-author:DickersonR... | lld:pubmed |
| pubmed-article:9469690 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9469690 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9469690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9469690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9469690 | pubmed:pagination | 170-4 | lld:pubmed |
| pubmed-article:9469690 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:meshHeading | pubmed-meshheading:9469690-... | lld:pubmed |
| pubmed-article:9469690 | pubmed:articleTitle | Effect of sustained endotoxemia on alpha1-adrenergic responsiveness in parenterally fed rats. | lld:pubmed |
| pubmed-article:9469690 | pubmed:affiliation | Department of Clinical Pharmacy, University of Tennessee, Memphis 38163, USA. | lld:pubmed |
| pubmed-article:9469690 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9469690 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9469690 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9469690 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
