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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0020281,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205409,
umls-concept:C0242606,
umls-concept:C0683278,
umls-concept:C0814999,
umls-concept:C0997233,
umls-concept:C1511563,
umls-concept:C2603343
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pubmed:issue |
4
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pubmed:dateCreated |
1998-3-24
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pubmed:abstractText |
Effects of new complex curcuminoids (cassumunin A and cassumunin B) isolated from tropical ginger, Zingiber cassumunar, were examined in dissociated rat thymocytes suffering from oxidative stress induced by 3 mM hydrogen peroxide by using a flow cytometer and ethidium bromide. The effects were compared with those of curcumin, a natural antioxidant, whose chemical structure is included in those of cassumunins A and B. Pretreatment of rat thymocytes with the respective cassumunins at concentrations ranging from 100 nM to 3 microM dose-dependently prevented the hydrogen peroxide (H2O2)-induced decrease in cell viability. It had the same action, although less effective, against the treatment with cassumunin A or B (3 microM) immediately after or 60 min after start of the oxidative stress. Respective potencies of cassumunins A and B in protecting the cells suffering from H2O2-induced oxidative stress were greater than that of curcumin. It is suggested that cassumunins A and B may possess a potent protective action on living cells suffering from oxidative stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-5198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9469642-Animals,
pubmed-meshheading:9469642-Antioxidants,
pubmed-meshheading:9469642-Azoles,
pubmed-meshheading:9469642-Cell Line,
pubmed-meshheading:9469642-Cell Survival,
pubmed-meshheading:9469642-Curcumin,
pubmed-meshheading:9469642-Deferoxamine,
pubmed-meshheading:9469642-Dimethyl Sulfoxide,
pubmed-meshheading:9469642-Dose-Response Relationship, Drug,
pubmed-meshheading:9469642-Ethidium,
pubmed-meshheading:9469642-Flow Cytometry,
pubmed-meshheading:9469642-Hydrogen Peroxide,
pubmed-meshheading:9469642-Organoselenium Compounds,
pubmed-meshheading:9469642-Oxidative Stress,
pubmed-meshheading:9469642-Rats,
pubmed-meshheading:9469642-Rats, Wistar,
pubmed-meshheading:9469642-Thymus Gland,
pubmed-meshheading:9469642-Zingiberales
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pubmed:year |
1997
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pubmed:articleTitle |
New curcuminoids isolated from Zingiber cassumunar protect cells suffering from oxidative stress: a flow-cytometric study using rat thymocytes and H2O2.
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pubmed:affiliation |
Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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