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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-2-26
|
| pubmed:abstractText |
There is evidence that immunoglobulin (Ig) E antibody may be a critical component of protective immunity against Schistosoma mansoni and S. haematobium reinfection. In the present study, 555 individuals aged 3-67 years infected with S.japonicum received praziquantel treatment before the transmission season commenced; 45 d later, blood samples from 265 individuals who had no S. japonicum egg in their stool were examined by enzyme-linked immunosorbent assay for specific isotypic antibodies. Single, non-conditional logistic regression analysis showed that exposure intensity, age, soluble egg antigen (SEA)-IgE, SEA-IgM and soluble adult worm antigen-IgG4 were relevant to reinfection; multiple, non-conditional logistic regression analysis showed that exposure intensity was still a significant factor for reinfection while the SEA-IgE antibody level was associated with resistance to reinfection with S. japonicum, with a protective index of 2.00. It is suggested that this population in an area endemic for schistosomiasis japonica exhibits acquired immunity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Antiplatyhelmintic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Praziquantel
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0035-9203
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
606-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9463682-Adolescent,
pubmed-meshheading:9463682-Adult,
pubmed-meshheading:9463682-Age Factors,
pubmed-meshheading:9463682-Aged,
pubmed-meshheading:9463682-Antibodies, Helminth,
pubmed-meshheading:9463682-Antiplatyhelmintic Agents,
pubmed-meshheading:9463682-Child,
pubmed-meshheading:9463682-Child, Preschool,
pubmed-meshheading:9463682-China,
pubmed-meshheading:9463682-Humans,
pubmed-meshheading:9463682-Immunoglobulin E,
pubmed-meshheading:9463682-Immunoglobulin G,
pubmed-meshheading:9463682-Immunoglobulin M,
pubmed-meshheading:9463682-Logistic Models,
pubmed-meshheading:9463682-Middle Aged,
pubmed-meshheading:9463682-Praziquantel,
pubmed-meshheading:9463682-Recurrence,
pubmed-meshheading:9463682-Schistosomiasis japonica
|
| pubmed:articleTitle |
Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum.
|
| pubmed:affiliation |
Molecular and Immunoparasitology Research Department, Nanjing Medical University, Nanjing, China.
|
| pubmed:publicationType |
Journal Article
|