Linked Life Data

9461017

Source:http://linkedlifedata.com/resource/pubmed/id/9461017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-2-19
pubmed:abstractText
A microphotometric analysis of nuclear DNA ploidy and detection of human papillomavirus (HPV) type 16 DNA was carried out in 50 cases of mild, moderate and severe dysplasia of the uterine cervix along with an equal number of matched controls in order to understand their relative importance in malignant progression of the disease in women. Twenty-two (44.0%) cases of dysplasia showed an aneuploid DNA pattern while positivity for high risk HPV type 16 DNA was found in twenty-three (46.0%) cases. Thirty-four women with twice confirmed mild and moderate dysplasia have been followed up for 24 months. Follow-up data revealed that eight (72.7%) of the 11 patients having an aneuploid DNA pattern and positivity for HPV 16 progressed to carcinoma in situ (CIS) compared to only one (4.4%) case which was positive for HPV 16 with a non-aneuploid DNA pattern. This suggests that a combined analysis of infection of high risk HPV type 16 and aneuploid DNA pattern may serve as an important biological indicator to predict the potential of precancerous lesions of the uterine cervix for progression to malignancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
DNA aneuploidy and infection of human papillomavirus type 16 in preneoplastic lesions of the uterine cervix: correlation with progression to malignancy.
pubmed:affiliation
Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, New Delhi, India.
pubmed:publicationType
Journal Article