| pubmed-article:9459148 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0220636 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9459148 | lifeskim:mentions | umls-concept:C0148345 | lld:lifeskim |
| pubmed-article:9459148 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9459148 | pubmed:dateCreated | 1998-2-19 | lld:pubmed |
| pubmed-article:9459148 | pubmed:abstractText | We undertook the present study to clarify the molecular mechanism of the effect of a new anti-cancer drug, vesnarinone, on a human salivary gland cancer cell line, TYS. We isolated TSC-22cDNA as avesnarinone-inducible gene from a cDNA library constructed from vesnarinone-treated TYS cells. TSC-22 was originally reported as a transforming growth factor (TGF)-beta-inducible gene. The expression of TSC-22 was up-regulated within a few hours after treatment with vesnarinone and was continued for 3 days. The level of TSC-22 mRNA in TYS cells was continuously increased until the cells reached confluency. Furthermore, the induction of TSC-22 by vesnarinone was inhibited by treatment with cycloheximide. When we treated the cells with an antisense oligonucleotide against TSC-22 mRNA under quiescent conditions, the antisense oligonucleotide stimulated the growth of TYS cells; however, under growing conditions the antisense oligonucleotide did not affect cell growth. Furthermore, the antisense oligonucleotide suppressed the antiproliferative effect of vesnarinone. These results suggest that TSC-22 may be a negative growth regulator and may play an important role in the antiproliferative effect of vesnarinone. | lld:pubmed |
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| pubmed-article:9459148 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9459148 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9459148 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9459148 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:SatoMM | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:YoshidaHH | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:HinoSS | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:KawamataHH | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:UchidaDD | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:NakashiroKK | lld:pubmed |
| pubmed-article:9459148 | pubmed:author | pubmed-author:OmoteharaFF | lld:pubmed |
| pubmed-article:9459148 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9459148 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:9459148 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9459148 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9459148 | pubmed:pagination | 71-8 | lld:pubmed |
| pubmed-article:9459148 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9459148 | pubmed:meshHeading | pubmed-meshheading:9459148-... | lld:pubmed |
| pubmed-article:9459148 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9459148 | pubmed:articleTitle | Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell. | lld:pubmed |
| pubmed-article:9459148 | pubmed:affiliation | Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Kuramoto, Japan. | lld:pubmed |
| pubmed-article:9459148 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9459148 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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