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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-19
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pubmed:abstractText |
We undertook the present study to clarify the molecular mechanism of the effect of a new anti-cancer drug, vesnarinone, on a human salivary gland cancer cell line, TYS. We isolated TSC-22cDNA as avesnarinone-inducible gene from a cDNA library constructed from vesnarinone-treated TYS cells. TSC-22 was originally reported as a transforming growth factor (TGF)-beta-inducible gene. The expression of TSC-22 was up-regulated within a few hours after treatment with vesnarinone and was continued for 3 days. The level of TSC-22 mRNA in TYS cells was continuously increased until the cells reached confluency. Furthermore, the induction of TSC-22 by vesnarinone was inhibited by treatment with cycloheximide. When we treated the cells with an antisense oligonucleotide against TSC-22 mRNA under quiescent conditions, the antisense oligonucleotide stimulated the growth of TYS cells; however, under growing conditions the antisense oligonucleotide did not affect cell growth. Furthermore, the antisense oligonucleotide suppressed the antiproliferative effect of vesnarinone. These results suggest that TSC-22 may be a negative growth regulator and may play an important role in the antiproliferative effect of vesnarinone.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-1339368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-1547942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-1587811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-1900458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-2156629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-2429552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-2573827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-3558984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-3802100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-7750082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-7908517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8001126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8119948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8125258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8139914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8161377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8197168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8614832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-8651929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9459148-9066726
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TSC22D1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/vesnarinone
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pubmed:status |
MEDLINE
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9459148-Antineoplastic Agents,
pubmed-meshheading:9459148-Cell Cycle,
pubmed-meshheading:9459148-Cell Division,
pubmed-meshheading:9459148-Humans,
pubmed-meshheading:9459148-Neoplasm Proteins,
pubmed-meshheading:9459148-Oligonucleotides, Antisense,
pubmed-meshheading:9459148-Quinolines,
pubmed-meshheading:9459148-RNA, Messenger,
pubmed-meshheading:9459148-Repressor Proteins,
pubmed-meshheading:9459148-Salivary Gland Neoplasms,
pubmed-meshheading:9459148-Transcription Factors,
pubmed-meshheading:9459148-Tumor Cells, Cultured,
pubmed-meshheading:9459148-Up-Regulation
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pubmed:year |
1998
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pubmed:articleTitle |
Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell.
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pubmed:affiliation |
Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Kuramoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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