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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-3-19
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pubmed:abstractText |
Changes occurring at the surface of a calcium phosphate coating when in contact with osteoblasts versus those in acellular solutions were analyzed. The coating studied is one with a well-documented extensive effect on short-term bone growth stimulation. Precipitates associated with original crystals and organized in a weblike structure were observed after a 3-week culture with osteoblasts. The precipitates were identified as carbonated hydroxyapatite (c-HA). In contrast, no significant surface changes were detected after immersion in an acellular serum-containing solution. However, in an acellular serum-free solution simulating the ionic composition of plasma, precipitates, identified as c-HA, were abundantly formed. Dissolution of the original coating preceded precipitation. The data support the hypothesis that dissolution of synthetic calcium phosphate ceramics is an initial step in their transformation to a biologically equivalent apatite, and suggest that both solution-mediated (dissolution-precipitation) and cell-mediated mechanisms are involved in the surface transformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9304
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-43
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9457553-Animals,
pubmed-meshheading:9457553-Animals, Newborn,
pubmed-meshheading:9457553-Blood Proteins,
pubmed-meshheading:9457553-Calcium Phosphates,
pubmed-meshheading:9457553-Ceramics,
pubmed-meshheading:9457553-Chemistry, Physical,
pubmed-meshheading:9457553-Immersion,
pubmed-meshheading:9457553-Metals,
pubmed-meshheading:9457553-Microscopy, Electron,
pubmed-meshheading:9457553-Models, Biological,
pubmed-meshheading:9457553-Osteoblasts,
pubmed-meshheading:9457553-Physicochemical Phenomena,
pubmed-meshheading:9457553-Rats,
pubmed-meshheading:9457553-Reproducibility of Results,
pubmed-meshheading:9457553-Solutions,
pubmed-meshheading:9457553-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:9457553-Surface Properties
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pubmed:year |
1998
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pubmed:articleTitle |
Effect of serum proteins and osteoblasts on the surface transformation of a calcium phosphate coating: a physicochemical and ultrastructural study.
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pubmed:affiliation |
Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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