| pubmed-article:945048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C0445623 | lld:lifeskim |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C0996377 | lld:lifeskim |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:945048 | lifeskim:mentions | umls-concept:C0048819 | lld:lifeskim |
| pubmed-article:945048 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:945048 | pubmed:dateCreated | 1976-8-2 | lld:pubmed |
| pubmed-article:945048 | pubmed:abstractText | Several compound containing a thiomethyl group were found to replace vitamin B12 in a protozoan, Ochromonas malhamensis. The order of the effectiveness was as follows: 5'-methylthioadenosine is greater than S-adenosylmethionine is greater than 5-methylthioribose is greater then L-methionine. A similar order was obtained with respect to the permeability of these compounds into the protozoan cells, except for S-adenosylmethionine. 5'-Methylthioadenosine and 5-methylthioribose as well as L-methionine markedly increased the intracellular content of L-methionine. The level of S-adenosylmethionine was also increased by them, but to lesser degree. The thiomethyl group of the compounds was established to be incorporated into S-adenosylmethionine. The metabolic fate of the thiomethyl group of 5'-methylthioadenosine cannot be distinguished from that of L-methionine. A high activity of 5'-methylthioadenosine nucleosidase was detected in the cell-free extracts of the protozoan. These results strongly suggest that 5'-methylthioadenosine would be metabolized to L-methionine would be ocnverted to S-adenosylmethionine. Like L-methionine and vitamin B12, 5'-methylthioadenosine and 5-methylthioribose may play an important role in maintenance of the C-1 pool in Ochromonas malhamensis. Neither 5'-methylthioadenosine nor 5-methylthioribose replaced vitamin B12 in some vitamin B12-requiring bacteria. This result is consistent with the fact that neither compounds was significantly taken up by these bacteria. | lld:pubmed |
| pubmed-article:945048 | pubmed:language | eng | lld:pubmed |
| pubmed-article:945048 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:945048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:945048 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:945048 | pubmed:issn | 0302-8933 | lld:pubmed |
| pubmed-article:945048 | pubmed:author | pubmed-author:FukuiSS | lld:pubmed |
| pubmed-article:945048 | pubmed:author | pubmed-author:SugimotoYY | lld:pubmed |
| pubmed-article:945048 | pubmed:author | pubmed-author:TorayaTT | lld:pubmed |
| pubmed-article:945048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:945048 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:945048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:945048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:945048 | pubmed:pagination | 175-82 | lld:pubmed |
| pubmed-article:945048 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-E... | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-M... | lld:pubmed |
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| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-R... | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-V... | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-N... | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-C... | lld:pubmed |
| pubmed-article:945048 | pubmed:meshHeading | pubmed-meshheading:945048-S... | lld:pubmed |
| pubmed-article:945048 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:945048 | pubmed:articleTitle | Studies on metabolic role of 5'-Methylthioadenosine in Ochromonas malhamensis and other microorganisms. | lld:pubmed |
| pubmed-article:945048 | pubmed:publicationType | Journal Article | lld:pubmed |
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