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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-13
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pubmed:abstractText |
Active colitis in patients with inflammatory bowel disease is associated with mucosal vasodilation, increased intestinal permeability and abnormal colonic motility. Nitric oxide is a messenger molecule with many functions, including regulation of local blood flow, vasomotor tone, and inflammation. Increased nitric oxide production and inducible nitric oxide synthase activity have been demonstrated in experimental models of colitis. This study was designed to determine the relationship between nitric oxide production and colonic inflammation in children with active colitis and in control subjects and whether expression of inducible nitric oxide synthase protein is demonstrable in the intestinal epithelium of these patients.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0277-2116
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-8
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:9443117-Adolescent,
pubmed-meshheading:9443117-Child,
pubmed-meshheading:9443117-Child, Preschool,
pubmed-meshheading:9443117-Colitis,
pubmed-meshheading:9443117-Colon,
pubmed-meshheading:9443117-Enzyme Induction,
pubmed-meshheading:9443117-Epithelium,
pubmed-meshheading:9443117-Feces,
pubmed-meshheading:9443117-Female,
pubmed-meshheading:9443117-Humans,
pubmed-meshheading:9443117-Immunohistochemistry,
pubmed-meshheading:9443117-Inflammatory Bowel Diseases,
pubmed-meshheading:9443117-Male,
pubmed-meshheading:9443117-Nitrates,
pubmed-meshheading:9443117-Nitric Oxide,
pubmed-meshheading:9443117-Nitric Oxide Synthase,
pubmed-meshheading:9443117-Nitric Oxide Synthase Type II,
pubmed-meshheading:9443117-Nitrites
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pubmed:year |
1998
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pubmed:articleTitle |
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease.
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pubmed:affiliation |
Division of Gastroenterology and Nutrition, Schneider Children's Hospital, New Hyde Park, NY 11040, USA.
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pubmed:publicationType |
Journal Article
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