| pubmed-article:9442015 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C0287990 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C1961133 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C2673177 | lld:lifeskim |
| pubmed-article:9442015 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9442015 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9442015 | pubmed:dateCreated | 1998-3-3 | lld:pubmed |
| pubmed-article:9442015 | pubmed:abstractText | Furin is a ubiquitous prototypical mammalian kexin/subtilisin-like endoproteinase that is involved in the proteolytic processing of a variety of proteins in the exocytic and endocytic pathways, with cleavage occurring at the C terminus of the minimal consensus furin recognition sequence Arg-Xaa-Xaa-Arg. In this study, human proteinase inhibitor 8 (PI8), a widely expressed 45-kDa ovalbumin-type serpin that contains two sequences homologous to the minimal sequence for recognition by furin in its reactive site loop, was tested for its ability to inhibit a recombinant soluble form of human furin. PI8 formed an SDS-stable complex with furin and inhibited its amidolytic activity via a two-step mechanism with a kappa assoc of 6.5 x 10(5) M-1 S-1 and an overall Ki of 53.8 pM. Thus, PI8 inhibits furin in a rapid, tight binding manner that is characteristic of physiological serpin-proteinase interactions. PI8 is not only the first human ovalbumin-type serpin to demonstrate inhibitory activity toward furin, but it is also the first significant inhibitor of furin identified that is not a serpin reactive site loop mutant, either naturally occurring or engineered. | lld:pubmed |
| pubmed-article:9442015 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442015 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9442015 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442015 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9442015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9442015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442015 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9442015 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9442015 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9442015 | pubmed:author | pubmed-author:ThomasGG | lld:pubmed |
| pubmed-article:9442015 | pubmed:author | pubmed-author:JeanFF | lld:pubmed |
| pubmed-article:9442015 | pubmed:author | pubmed-author:KisielWW | lld:pubmed |
| pubmed-article:9442015 | pubmed:author | pubmed-author:FosterD CDC | lld:pubmed |
| pubmed-article:9442015 | pubmed:author | pubmed-author:DahlenJ RJR | lld:pubmed |
| pubmed-article:9442015 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9442015 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:9442015 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9442015 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9442015 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9442015 | pubmed:pagination | 1851-4 | lld:pubmed |
| pubmed-article:9442015 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9442015 | pubmed:meshHeading | pubmed-meshheading:9442015-... | lld:pubmed |
| pubmed-article:9442015 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9442015 | pubmed:articleTitle | Inhibition of soluble recombinant furin by human proteinase inhibitor 8. | lld:pubmed |
| pubmed-article:9442015 | pubmed:affiliation | Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131, USA. | lld:pubmed |
| pubmed-article:9442015 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9442015 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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