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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-3-20
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pubmed:abstractText |
The contextual specificity of appetitive conditioned responding was examined in rats undergoing chronic intracerebroventricular infusion of 15 or 30 mM D-2-amino-5-phosphonopentanoic acid (D-AP5) or with excitotoxic hippocampal lesions. The magnitude of conditioned responding by control rats and rats infused with D-AP5 to a conditioned stimulus (CS) trained in Context A was attenuated when the same stimulus was presented in Context B. By contrast, hippocampal-lesioned rats displayed comparable levels of responding to the CS when presented in either Context A or B. Subsequent in vivo electrophysiological investigations showed that the D-AP5 concentrations were effective in blocking long-term potentiation (LTP) in the dentate gyrus. Results indicate that rats are capable of processing contextual information in the absence of N-methyl-D-aspartate (NMDA) receptor-dependent LTP and demonstrate an important dissociation between the effects of hippocampal lesions and the blockade of NMDA receptors in the hippocampus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0735-7044
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9438787-2-Amino-5-phosphonovalerate,
pubmed-meshheading:9438787-Animals,
pubmed-meshheading:9438787-Appetitive Behavior,
pubmed-meshheading:9438787-Conditioning (Psychology),
pubmed-meshheading:9438787-Cues,
pubmed-meshheading:9438787-Discrimination Learning,
pubmed-meshheading:9438787-Excitatory Amino Acid Agonists,
pubmed-meshheading:9438787-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9438787-Excitatory Postsynaptic Potentials,
pubmed-meshheading:9438787-Hippocampus,
pubmed-meshheading:9438787-Ibotenic Acid,
pubmed-meshheading:9438787-Infusion Pumps, Implantable,
pubmed-meshheading:9438787-Long-Term Potentiation,
pubmed-meshheading:9438787-Male,
pubmed-meshheading:9438787-Memory,
pubmed-meshheading:9438787-Rats,
pubmed-meshheading:9438787-Rats, Inbred Strains,
pubmed-meshheading:9438787-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9438787-Stereotaxic Techniques
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pubmed:year |
1997
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pubmed:articleTitle |
Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-D-aspartate receptor-dependent long-term potentiation on contextual processing in rats.
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pubmed:affiliation |
Centre for Neuroscience, University of Edinburgh, Scotland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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