|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1998-1-22
|
|
pubmed:abstractText |
Peripheral and central immune mechanisms contribute to the induction of tolerance in acute rejection rodent transplant models after systemic administration of CTLA4Ig and intrathymic infusion of donor alloantigen, respectively. We have investigated the effects of CTLA4Ig-induced blockade of CD28-B7 T-cell co-stimulation in conjunction with intrathymic immunomodulation on cellular and humoral immune responses leading to accelerated rejection of cardiac allografts in presensitized rats.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0041-1337
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
64
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1816-22
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9422425-Adjuvants, Immunologic,
pubmed-meshheading:9422425-Animals,
pubmed-meshheading:9422425-Antigens, CD,
pubmed-meshheading:9422425-Antigens, CD28,
pubmed-meshheading:9422425-Antigens, CD80,
pubmed-meshheading:9422425-Antigens, Differentiation,
pubmed-meshheading:9422425-CTLA-4 Antigen,
pubmed-meshheading:9422425-Cytotoxicity, Immunologic,
pubmed-meshheading:9422425-Graft Rejection,
pubmed-meshheading:9422425-Immunoconjugates,
pubmed-meshheading:9422425-Immunoglobulin G,
pubmed-meshheading:9422425-Immunoglobulin M,
pubmed-meshheading:9422425-Isoantibodies,
pubmed-meshheading:9422425-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:9422425-Male,
pubmed-meshheading:9422425-Rats,
pubmed-meshheading:9422425-Rats, Inbred BN,
pubmed-meshheading:9422425-Rats, Inbred Lew,
pubmed-meshheading:9422425-Rats, Inbred WF,
pubmed-meshheading:9422425-Skin Transplantation,
pubmed-meshheading:9422425-Survival Analysis,
pubmed-meshheading:9422425-T-Lymphocytes,
pubmed-meshheading:9422425-Thymus Gland
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
CD28-B7 T-cell co-stimulatory blockade potentiates the effects of intrathymic immunomodulation in sensitized graft recipients.
|
|
pubmed:affiliation |
Harvard Medical School, and Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
