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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-1-16
|
| pubmed:abstractText |
It has been reported that genes regulating apoptosis may play a role in tumoral angiogenesis. This study examined the relationship between tumour vascularization, a measure of tumour angiogenesis, and bcl-2 and p53 expression in operable non-small-cell lung cancer (NSCLC). The relationship between bcl-2, p53 and tumour vascularization and epidermal-growth-factor-receptor(EGFR) and c-erbB-2 expression was also studied. Tissue sections from resected tumour specimens of 107 NSCLC patients were evaluated immunohistochemically for vascular grade and bcl-2, p53, EGFR and c-erbB-2 expression. bcl-2 expression was found in 20/107 (19%) cases and was associated with squamous-cell histology (p = 0.03). A strong inverse relationship was found between bcl-2 expression and vascular grade (p = 0.005). All c-erbB-2-positive cases were negative for bcl-2 expression (p = 0.01). Overall no association was found between c-erbB-2 expression and vascular grade. However, in bcl-2-negative cases positive c-erbB-2 expression correlated with low angiogenesis (p = 0.05). No relationship was found between p53 and EGFR expression and bcl-2, c-erbB-2 or vascular grade. The improved prognosis reported in bcl-2-positive NSCLC may be related to low tumour vascularization. The results suggest that the anti-apoptotic gene bcl-2 plays a role in regulating tumour angiogenesis. Since normal lung epithelium expresses bcl-2, a sequence of tumour progression involving loss of bcl-2, then activation of c-erbB-2 or increase in tumour vascularization is proposed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
565-70
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9421349-Aged,
pubmed-meshheading:9421349-Analysis of Variance,
pubmed-meshheading:9421349-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:9421349-Female,
pubmed-meshheading:9421349-Gene Expression,
pubmed-meshheading:9421349-Genes, Tumor Suppressor,
pubmed-meshheading:9421349-Genes, bcl-2,
pubmed-meshheading:9421349-Genes, p53,
pubmed-meshheading:9421349-Humans,
pubmed-meshheading:9421349-Lung Neoplasms,
pubmed-meshheading:9421349-Male,
pubmed-meshheading:9421349-Middle Aged,
pubmed-meshheading:9421349-Neovascularization, Pathologic,
pubmed-meshheading:9421349-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9421349-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9421349-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9421349-Retrospective Studies,
pubmed-meshheading:9421349-Survival Analysis,
pubmed-meshheading:9421349-Tumor Suppressor Protein p53
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer.
|
| pubmed:affiliation |
ICRF Medical Oncology Unit, Radcliffe Hospital, Oxford, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|