Linked Life Data

9420025

Source:http://linkedlifedata.com/resource/pubmed/id/9420025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-1-29
pubmed:abstractText
We describe a new modality for administering aminoglycosides to hemodialysis (HD) patients, namely, a modification of the once-daily regimen which consists of administering the aminoglycosides over 60 min by drip infusion just before each HD session, with a preplanned peak concentration being reached at the beginning of the session and then with a rapidly decreasing concentration being achieved by the start of HD. The area under the concentration-time curve (AUC), i.e., the accumulation of the drug in the body, is thus minimized by this modality. Arbekacin (ABK) was given at a dose of 2 mg/kg of body weight to 10 HD patients infected with methicillin-resistant Staphylococcus aureus (MRSA) for 2 weeks (six sessions in total), resulting in the complete disappearance of MRSA in 5 patients. A high rate of elimination of ABK was attained for each patient while the patient was on HD (range, 0.20 to 0.42 h-1; mean 0.28 +/- 0.08 h-1) by using high-performance dialyzers provided with membranes made of either polymethylmethacrylate, cellulose triacetate (CTA), or ethylene vinyl alcohol. The best results were obtained with the CTA membrane, as revealed by the overall mass transfer coefficient (Ko). The AUC in the simulation model for the variation in the serum ABK concentration in this modality was calculated to be 40% of that of the conventional post-HD dosing modality, suggesting that a much higher dose could be administered to HD patients who receive HD thrice weekly (4 h per session), giving, e.g., 4 mg/kg initially and before the HD sessions, when there is an interval of 68 h from HD session to HD session, and giving 2 mg/kg before the other sessions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-2039189, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-2106415, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-2671137, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-3606062, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-3710965, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-4209533, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-5960730, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-7559197, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-7654477, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-7758394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-8072172, http://linkedlifedata.com/resource/pubmed/commentcorrection/9420025-8352256
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2597-601
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Administration of aminoglycosides to hemodialysis patients immediately before dialysis: a new dosing modality.
pubmed:affiliation
Dialysis Center, Hidaka Hospital, Takasaki, Gunma Prefecture, Japan.
pubmed:publicationType
Journal Article, Clinical Trial