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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-12-29
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pubmed:databankReference |
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pubmed:abstractText |
Chloroquine resistance in a P. falciparum cross maps as a Mendelian trait to a 36 kb segment of chromosome 7. This segment harbors cg2, a gene encoding a unique approximately 330 kDa protein with complex polymorphisms. A specific set of polymorphisms in 20 chloroquine-resistant parasites from Asia and Africa, in contrast with numerous differences in 21 sensitive parasites, suggests selection of a cg2 allele originating in Indochina over 40 years ago. One chloroquine-sensitive clone exhibited this allele, suggesting another resistance component. South American parasites have cg2 polymorphisms consistent with a separate origin of resistance. CG2 protein is found at the parasite periphery, a site of chloroquine transport, and in association with hemozoin of the digestive vacuole, where chloroquine inhibits heme polymerization.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-603
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9393853-Africa,
pubmed-meshheading:9393853-Amino Acid Sequence,
pubmed-meshheading:9393853-Animals,
pubmed-meshheading:9393853-Antimalarials,
pubmed-meshheading:9393853-Asia, Southeastern,
pubmed-meshheading:9393853-Chloroquine,
pubmed-meshheading:9393853-Chromosome Mapping,
pubmed-meshheading:9393853-Crossing Over, Genetic,
pubmed-meshheading:9393853-DNA, Protozoan,
pubmed-meshheading:9393853-DNA, Satellite,
pubmed-meshheading:9393853-Drug Resistance, Microbial,
pubmed-meshheading:9393853-Erythrocytes,
pubmed-meshheading:9393853-Genetic Linkage,
pubmed-meshheading:9393853-Molecular Sequence Data,
pubmed-meshheading:9393853-Pan troglodytes,
pubmed-meshheading:9393853-Plasmodium falciparum,
pubmed-meshheading:9393853-Polymorphism, Genetic,
pubmed-meshheading:9393853-Protozoan Proteins,
pubmed-meshheading:9393853-Sequence Analysis, DNA,
pubmed-meshheading:9393853-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa.
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pubmed:affiliation |
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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