Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-1-2
pubmed:databankReference
pubmed:abstractText
shuA encodes a 70-kDa outer membrane heme receptor in Shigella dysenteriae. Analysis of the shuA DNA sequence indicates that this gene encodes a protein with homology to TonB-dependent receptors of gram-negative bacteria. Transport of heme by the ShuA protein requires TonB and its accessory proteins ExbB and ExbD. The shuA DNA sequence contains a putative Fur box overlapping the -10 region of a potential shuA promoter, and the expression of shuA is repressed by exogenous iron or hemin in a Fur-dependent manner, although hemin repressed expression to a lesser extent than iron salts. Disruption of this open reading frame on the S. dysenteriae chromosome by marker exchange yielded a strain that failed to use heme as an iron source, indicating that shuA is essential for heme transport in S. dysenteriae. However, shuA is not essential for invasion or multiplication within cultured Henle cells; the shuA mutant invaded and produced normal plaques in confluent cell monolayers.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-1100846, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-1809832, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-1830293, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2055470, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2644220, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2644221, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2851488, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2963952, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2964410, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2971620, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-2999794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-3001021, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-3025098, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-3028962, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-3062182, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-3884506, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-6090419, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-6224775, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-7012026, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-7751272, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-7768795, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-7937909, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-8096622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-8195082, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-8384684, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-9009350, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-9026634, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-9157252, http://linkedlifedata.com/resource/pubmed/commentcorrection/9393841-9171402
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5358-63
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Identification of shuA, the gene encoding the heme receptor of Shigella dysenteriae, and analysis of invasion and intracellular multiplication of a shuA mutant.
pubmed:affiliation
Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin 78712, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.