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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-12-17
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pubmed:abstractText |
TRAF2 is an intracellular signal-transducing protein recruited to the TNFR1 and TNFR2 receptors following TNF stimulation. To investigate the physiological role of TRAF2, we generated TRAF2-deficient mice. traf2-/- mice appeared normal at birth but became progressively runted and died prematurely. Atrophy of the thymus and spleen and depletion of B cell precursors also were observed. Thymocytes and other hematopoietic progenitors were highly sensitive to TNF-induced cell death and serum TNF levels were elevated in these TRAF2-deficient animals. Examination of traf2-/- cells revealed a severe reduction in TNF-mediated JNK/SAPK activation but a mild effect on NF-kappaB activation. These results suggest that TRAF2-independent pathways of NF-kappaB activation exist and that TRAF2 is required for an NF-kappaB-independent signal that protects against TNF-induced apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:BilliaFF,
pubmed-author:FerrickDD,
pubmed-author:GoeddelD VDV,
pubmed-author:HuqFF,
pubmed-author:IscoveNN,
pubmed-author:KraunusJJ,
pubmed-author:MaoT STS,
pubmed-author:OhashiPP,
pubmed-author:RotheMM,
pubmed-author:ShahinianAA,
pubmed-author:SpeiserDD,
pubmed-author:WakehamAA,
pubmed-author:YeeW HWH,
pubmed-author:de la PompaJ LJL
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
715-25
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9390694-Animals,
pubmed-meshheading:9390694-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9390694-Cell Death,
pubmed-meshheading:9390694-Cycloheximide,
pubmed-meshheading:9390694-Enzyme Activation,
pubmed-meshheading:9390694-Female,
pubmed-meshheading:9390694-Hematopoietic Stem Cells,
pubmed-meshheading:9390694-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9390694-Liver,
pubmed-meshheading:9390694-Male,
pubmed-meshheading:9390694-Mice,
pubmed-meshheading:9390694-Mice, Inbred C57BL,
pubmed-meshheading:9390694-Mice, Knockout,
pubmed-meshheading:9390694-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9390694-NF-kappa B,
pubmed-meshheading:9390694-Protein Synthesis Inhibitors,
pubmed-meshheading:9390694-Proteins,
pubmed-meshheading:9390694-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9390694-Signal Transduction,
pubmed-meshheading:9390694-TNF Receptor-Associated Factor 2,
pubmed-meshheading:9390694-Tumor Necrosis Factor-alpha
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pubmed:year |
1997
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pubmed:articleTitle |
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
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pubmed:affiliation |
Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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