Linked Life Data

9387201

Source:http://linkedlifedata.com/resource/pubmed/id/9387201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-1-20
pubmed:abstractText
For patients with high platelet counts an inverse relationship has been established between platelet counts and large vWf multimers in plasma. Platelets are currently thought to be primarily involved in the pathogenesis of this decrease in plasma large vWf multimers, presumably by binding large vWf multimers, resulting in their effective removal from the circulation and/or by degrading (platelet-bound) vWf. In patients with myeloproliferative disorders associated with high platelet counts, a decrease in large vWf multimers in plasma may potentially compromise primary hemostasis. Patients with reactive thrombocytosis exhibit a similar reduction in large vWf multimers in plasma, but their clinical course is usually not complicated by bleeding, probably as a consequence of increased circulating vWf levels due to the behavior of vWf as a reactive protein, which compensates for the relatively decreased levels of large vWf multimers in plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0094-6176
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Acquired von Willebrand disease in patients with high platelet counts.
pubmed:affiliation
Blood Coagulation Laboratory, Lab. Association Keeser & Arndt, Hamburg, Germany.
pubmed:publicationType
Journal Article, Case Reports