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rdf:type |
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lifeskim:mentions |
umls-concept:C0000854,
umls-concept:C0004927,
umls-concept:C0205178,
umls-concept:C0205460,
umls-concept:C0221102,
umls-concept:C0302934,
umls-concept:C0600688,
umls-concept:C1167624,
umls-concept:C1515655,
umls-concept:C1548779,
umls-concept:C1704711,
umls-concept:C1947902,
umls-concept:C2827499
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pubmed:issue |
6
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pubmed:dateCreated |
1998-1-15
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pubmed:abstractText |
Water-soluble fullerenes have recently been shown to exhibit considerable in vitro biological activity including cytotoxicity, site-selective DNA cleavage and inhibition of HIV protease. To assess the potential of these compounds as drugs, studies on the in vivo behavior of fullerenes are needed. We therefore set out to synthesize a radiolabeled, water-soluble fullerene, in order to obtain data on the oral absorption, distribution and excretion of this class of compounds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9383440-Administration, Oral,
pubmed-meshheading:9383440-Animals,
pubmed-meshheading:9383440-Blood-Brain Barrier,
pubmed-meshheading:9383440-Carbon,
pubmed-meshheading:9383440-Chemistry, Physical,
pubmed-meshheading:9383440-Feces,
pubmed-meshheading:9383440-Female,
pubmed-meshheading:9383440-Fullerenes,
pubmed-meshheading:9383440-Indicators and Reagents,
pubmed-meshheading:9383440-Injections, Intravenous,
pubmed-meshheading:9383440-Isotope Labeling,
pubmed-meshheading:9383440-Male,
pubmed-meshheading:9383440-Mice,
pubmed-meshheading:9383440-Mice, Inbred Strains,
pubmed-meshheading:9383440-Physicochemical Phenomena,
pubmed-meshheading:9383440-Rats,
pubmed-meshheading:9383440-Rats, Inbred F344,
pubmed-meshheading:9383440-Solubility,
pubmed-meshheading:9383440-Tissue Distribution,
pubmed-meshheading:9383440-Water
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pubmed:year |
1995
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pubmed:articleTitle |
In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity.
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pubmed:affiliation |
Department of Chemistry, Tokyo Institute of Technology, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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