| pubmed-article:9383059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9383059 | lifeskim:mentions | umls-concept:C0017347 | lld:lifeskim |
| pubmed-article:9383059 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9383059 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:9383059 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9383059 | pubmed:dateCreated | 1998-2-5 | lld:pubmed |
| pubmed-article:9383059 | pubmed:abstractText | Genetic variation affecting the expressivity of an amorphic allele of the homeotic gene Ultrabithorax, (Ubx1) was characterized after 11 generations of introgression into 29 different isofemale lines. Heterozygotes display a range of haploinsufficient phenotypes, from overlap with wild-type halteres to dramatic transformations such as a 50% increase in area and the presence of over 20 bristles on the anterior margin of each haltere. In both the wild-type and mutant genetic backgrounds, there is moderate genetic variance and low environmental variance/developmental asymmetry, as expected of a trait under stabilizing selection pressure. Surprisingly, there is little evidence that mutant halteres are more variable than wild-type ones, so it is unclear that haltere development is also canalized. The correlation between wild-type and Ubx haltere size is very low, indicating that interactions among modifiers of Ubx are complex, and in some cases sex-specific. The potential quantitative genetic contributions of homeotic genes to appendage morphology are discussed, noting that population-level effects of variation in key regulatory genes may be prevalent and complex but cannot be readily extrapolated to macroevolutionary diversification. | lld:pubmed |
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| pubmed-article:9383059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9383059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9383059 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9383059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9383059 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9383059 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:9383059 | pubmed:author | pubmed-author:GibsonGG | lld:pubmed |
| pubmed-article:9383059 | pubmed:author | pubmed-author:van HeldenSS | lld:pubmed |
| pubmed-article:9383059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9383059 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:9383059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9383059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9383059 | pubmed:pagination | 1155-68 | lld:pubmed |
| pubmed-article:9383059 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9383059 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9383059 | pubmed:articleTitle | Is function of the Drosophila homeotic gene Ultrabithorax canalized? | lld:pubmed |
| pubmed-article:9383059 | pubmed:affiliation | Department of Biology, The University of Michigan, Ann Arbor 48109-1048, USA. ggibson@umich.edu | lld:pubmed |
| pubmed-article:9383059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9383059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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