Linked Life Data

9382567

Source:http://linkedlifedata.com/resource/pubmed/id/9382567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-11-10
pubmed:abstractText
Repeated exposure to UV radiation from the sun causes premature skin aging. This photoaging is characterized by wrinkles, mottled pigmentations, dry and rough skin, and loss of skin tone. Since the clinical demonstration that the use of topical tretinoin can improve photoaged skin, a great deal of knowledge that may explain wrinkle effacement has been acquired. Central to this pursuit has been dermal collagen. In this article, we summarize evidence (mainly from humans) that implicates a deficiency of superficial dermal collagen as the cause of the dermal aspects of photoaging. In addition, a mechanism through which UV radiation can lead to reduced collagen is presented. Through our understanding of the pathophysiological mechanism of photoaging, our ability to treat and possibly prevent this skin condition is enhanced.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-987X
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1280-4
pubmed:dateRevised
2008-3-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.
pubmed:affiliation
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't