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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1997-11-12
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pubmed:abstractText |
The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body weight i.p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-1323840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-1324683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-1472092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-1544708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-1855478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-2078793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-2156257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-2200555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-3013595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-435363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-4356680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-6257495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-6307514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-6324995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-7669228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8071654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8384066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8425767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8472160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8645577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-8720668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-942051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376260-9831485
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1017-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9376260-Adenocarcinoma,
pubmed-meshheading:9376260-Animals,
pubmed-meshheading:9376260-Antineoplastic Agents,
pubmed-meshheading:9376260-Calcitriol,
pubmed-meshheading:9376260-Cell Division,
pubmed-meshheading:9376260-Dose-Response Relationship, Drug,
pubmed-meshheading:9376260-Female,
pubmed-meshheading:9376260-Humans,
pubmed-meshheading:9376260-Mice,
pubmed-meshheading:9376260-Mice, Nude,
pubmed-meshheading:9376260-Neoplasm Transplantation,
pubmed-meshheading:9376260-Pancreatic Neoplasms,
pubmed-meshheading:9376260-Receptors, Calcitriol,
pubmed-meshheading:9376260-Transplantation, Heterologous,
pubmed-meshheading:9376260-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro.
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pubmed:affiliation |
Division of Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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