Linked Life Data

9372866

Source:http://linkedlifedata.com/resource/pubmed/id/9372866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-12-10
pubmed:abstractText
The use of PSA in the diagnosis of prostate cancer is controversial. This is due to false-positive results caused by benign prostatic hyperplasia (BPH). Different forms of circulating PSA have recently been described. Initial studies indicate that the fraction of free PSA is lower in prostate cancer than in BPH, therefore suggesting that its measurement could be of some diagnostic value. We have assessed the serum value of the percentage of free/total PSA in the differential diagnosis of BPH and prostate cancer. The levels of PSA and free PSA (DELFIA) were measured in 145 BPH patients and 56 prostate cancer patients. Free PSA is a small fraction of PSA, and significantly lower levels are being found in prostate cancer. In those patients with a PSA level between 2 and 25 micrograms/l, the determination of the percentage of free PSA increased the diagnostic efficiency of PSA, while reducing the number of negative biopsies. We conclude that free PSA may be a useful marker for the diagnosis of prostate cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1010-4283
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
332-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Free and total PSA in the diagnosis of prostate cancer.
pubmed:affiliation
Department of Clinical Biochemistry, Hospital Clínic i Provincial, Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't