Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-1-2
pubmed:abstractText
The present study examined the nociceptive responses (50 degrees C, hot-plate) of uninfected and subclinically parasitized male mice exposed to the odor of a predator, an ecologically relevant threatening stimulus. In uninfected mice a 15-min exposure to 2-propylthietane, the major component of weasel odor, induced a naloxone-reversible opioid analgesia. A 30-s exposure elicited a shorter duration and lower amplitude 'non-opioid' analgesia that was insensitive to naloxone, partially sensitive to either the serotonin-1A (5-HT1A) agonist, 8-OH-DPAT, or the GABAA antagonist, bicuculline, and blocked by the competitive N-methyl-D-aspartate (NMDA) antagonist, NPC 12626. In contrast, mice chronically (25 days) and subclinically infected with the murine nematode, Heligmosomoides polygyrus, failed to show a significant non-opioid analgesia and displayed a markedly lower level of opioid analgesia than uninfected mice. These results suggest that NMDA receptor mechanisms are potently associated with the expression of the analgesia arising from exposure to the naturally aversive stimulus of predator odor. These findings also demonstrate that parasites, and likely other subchronic infections, can have a significant impact on the display of opioid and non-opioid stress-induced analgesia arising from exposure to the ethologically relevant stimulus of predator odor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral..., http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids, http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline, http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acid, http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acids, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Histamine Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/NPC 12626, http://linkedlifedata.com/resource/pubmed/chemical/Naloxone, http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
766
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:9359582-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:9359582-Amino Acids, pubmed-meshheading:9359582-Analgesia, pubmed-meshheading:9359582-Animals, pubmed-meshheading:9359582-Behavior, Animal, pubmed-meshheading:9359582-Bicuculline, pubmed-meshheading:9359582-Butyric Acid, pubmed-meshheading:9359582-Butyric Acids, pubmed-meshheading:9359582-Excitatory Amino Acid Antagonists, pubmed-meshheading:9359582-GABA Antagonists, pubmed-meshheading:9359582-Histamine Antagonists, pubmed-meshheading:9359582-Host-Parasite Interactions, pubmed-meshheading:9359582-Male, pubmed-meshheading:9359582-Mice, pubmed-meshheading:9359582-Mice, Inbred Strains, pubmed-meshheading:9359582-Naloxone, pubmed-meshheading:9359582-Narcotic Antagonists, pubmed-meshheading:9359582-Nematospiroides dubius, pubmed-meshheading:9359582-Nociceptors, pubmed-meshheading:9359582-Odors, pubmed-meshheading:9359582-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:9359582-Receptors, Opioid, pubmed-meshheading:9359582-Serotonin Receptor Agonists, pubmed-meshheading:9359582-Stress, Physiological, pubmed-meshheading:9359582-Strongylida Infections, pubmed-meshheading:9359582-Time Factors
pubmed:year
1997
pubmed:articleTitle
Opioid and non-opioid NMDA-mediated predator-induced analgesia in mice and the effects of parasitic infection.
pubmed:affiliation
Division of Oral Biology, Faculty of Dentistry, University of Western Ontario, London, Canada. kavalier@julian.uwo.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't