rdf:type |
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0040845,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0449774,
umls-concept:C0684249,
umls-concept:C0851827,
umls-concept:C1518174,
umls-concept:C1701901,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
1997-11-25
|
pubmed:databankReference |
|
pubmed:abstractText |
The expression patterns of the class I homeogenes HOXB and HOXC clusters in the presence of retinoic acid (RA) were studied in two human small-cell lung cancer (SCLC) cell lines and compared to that of NT2/D1 embryonal carcinoma cells. Contrasting with the sequential 3'-5' induction of the HOX genes observed after RA treatment of embryonic NT2/D1 cells, in the SCLC cells the responding genes (induced or down-regulated) were interspersed with insensitive genes (expressed or unexpressed), while no genomic alteration affected the corresponding clusters. These findings imply that HOX gene regulatory mechanisms are altered in non-embryonic SCLC cells, perhaps reflecting their ability to respond to more diversified stimuli, in relation with their origin from adult tissues.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
415
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
263-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9357979-Carcinoma, Small Cell,
pubmed-meshheading:9357979-DNA Primers,
pubmed-meshheading:9357979-Electrophoresis, Agar Gel,
pubmed-meshheading:9357979-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9357979-Genes, Homeobox,
pubmed-meshheading:9357979-Homeodomain Proteins,
pubmed-meshheading:9357979-Humans,
pubmed-meshheading:9357979-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:9357979-Polymerase Chain Reaction,
pubmed-meshheading:9357979-RNA, Neoplasm,
pubmed-meshheading:9357979-RNA-Directed DNA Polymerase,
pubmed-meshheading:9357979-Tretinoin,
pubmed-meshheading:9357979-Tumor Cells, Cultured
|
pubmed:year |
1997
|
pubmed:articleTitle |
Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.
|
pubmed:affiliation |
Institut Curie - CNRS, UMR 147, Paris, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|